Biochemistry
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From the bench to biotech executive: Alum Lori Rudolph-Owen’s career path
Lori Rudolph-Owen, an accomplished figure in the biotechnology industry and a Vanderbilt University School of Medicine Basic Sciences alum, shared her insights on career progression and drug development on Oct. 3 as part of BRET’s Ph.D. Career Stories, a series focused on various alums and their professions. Read MoreDec. 17, 2024
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Unmasking antagonists: a deep dive into the structural binding poses of PPARγ ligands
Doug Kojetin, associate professor of biochemistry, and a collaborator from the Guangzhou Laboratory, use NMR and crystallography to elucidate the binding pose of GW9662 and T0070907 cobound with synthetic ligands for the first time. Read MoreDec. 13, 2024
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Vanderbilt awarded up to $46M through ARPA-H to develop tools against alphaviruses
Jens Meiler, Distinguished Research Professor of Chemistry and Kevin Schey, Stevenson Chair and professor of biochemistry, are two Vanderbilt collaborators on the project that brings together specialists in virology, structural biology and clinical research to tackle the complex challenge of vaccine development. Read MoreDec. 2, 2024
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Neil Osheroff elected Fellow of the Australia and New Zealand Association for Health Professional Educators
The only elected fellow outside of Oceania and Southeast Asia, Neil Osheroff brings four decades of medical education to the highly regarded health professional educator association ANZAHPE. Read MoreNov. 22, 2024
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Looking in all directions: Exploring a new horizon for PCOS therapeutics
Polycystic ovarian syndrome is a complex endocrinological disorder with widespread prevalence, affecting approximately one in ten women worldwide. Treatment for PCOS typically involves extensive lifestyle modification and medications to help manage reproductive symptoms and insulin resistance, but there are no treatments that directly target hyperandrogenism. Because of this, women with PCOS often feel unsatisfied with the quality of their care and are belabored by the changes necessary to live out their daily lives. Read MoreNov. 18, 2024
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New structure gives insight into mRNA export and cancers, and how viruses hijack the process to infect their host
A newly determined structure from the lab of Yi Ren reveals information about the mRNA export pathway and suggests that herpes viruses could hijack that interaction to infect their host. The new structures also reveal how certain mutations in the protein complex could play a role in cancers. Read MoreNov. 14, 2024
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Celebrating recent appointments and promotions in the School of Medicine Basic Sciences
Congratulations to our School of Medicine Basic Sciences members who were promoted or received new appointments from July to September 2024. These individuals significantly enrich our pursuit of pathbreaking research and contribute to the growth and success of our school. Read MoreNov. 14, 2024
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Nobel laureate Venki Ramakrishnan talks aging, mortality, and scientific innovation in Apex Lecture
Nobel Prize winner Venki Ramakrishnan delivered a captivating talk as part of the School of Medicine Basic Sciences Apex Lecture Series. His presentation was based on his best-selling book, Why We Die, which explores the biological mechanisms behind aging and death and humanity's efforts to prolong life. Read MoreNov. 14, 2024
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Jenny Tran wins 2025 Dr. Anne Karpay Award in Structural Biology
As a fifth-year graduate student in the Biochemistry Graduate Program, Jenny focuses on dissecting the allostery involved in heme biosynthesis initiation using an integrated structural biology approach in the lab of Professor Breann Brown. Her work has led to collaborations with other Vanderbilt labs, including the labs of Jens Meiler, John Yang and Jason MacGurn. Read MoreNov. 12, 2024
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Vanderbilt University School of Medicine Basic Sciences adds Carterra’s LSAXT instrument to speed drug and vaccine research and advance patient care
The Center for Structural Biology in the School of Medicine Basic Sciences will be a hub of research innovation using Carterra’s platform in traditional and AI-driven workflows for characterizing both antibodies and other biomolecules Read MoreSep. 25, 2024